Preparations for biorevitalisation skin based on polynucleotides - PLATSENTEKS and PLINEST In recent decades, an increasing number of research laboratories working in the field of anti-aging cosmetics. The highest achievement are cosmetic formulation designed to stimulate the natural processes in the body that fade with age. Lack of side effects and prolonged effect are essential in modern cosmetology. Most of the clients, patients, clinics and beauty salons are interested in the effects of a particular procedure, the opportunities of modern cosmetology, can neutralize or correct defects, obtained after injuries of various etiologies or surgical operations. Many of them are concerned about fading turgor of the skin, wrinkles appear due to various reasons related to stress, disease, age. Possibilities of contemporary no-hardware cosmetology can satisfy the most demanding of clientele, who do not want to resort to plastic surgery or not having time for the rehabilitation period after such operations. Their desire to look fresh, younger than in the shortest time and without surgical intervention is quite natural in an age of rapidly developing technologies of physical and biological anti-aging medicine and cosmetology. Thus, on the market of cosmetic services, products based on hyaluronic acid, are a great way to increase metabolism and normalization "of tissue respiration, skin, restoring the synthesis of collagen and elastin, and thus the skin tone that is characteristic of a young age. Cosmetic effects of their use becomes more pronounced when combined with their preparations for contour plastics, chemical peeling, Botox injections and other rejuvenating treatments ... Procedures are recommended cycles: one procedure once a month (3 -4 sessions). The next cycle - six months after the end of the first cycle. Despite a slow decrease in hyaluronic acid, the amount of water retained in the dermis does not change, that is still the initial level of tissues as resorption of the product. This ensures long-term cosmetic effects of 4 to 8 months. Some time ago, an agent "Placentex", referring to the group regenerates animal origin, produced from the milk of trout. This drug may not only enhance the action of "filling" wrinkles - hyaluronic acid, collagen, prolongiruya their effect, but also independently stimulate collagen synthesis in the small wrinkles and the formation of new tissue structures in the rumen, the scars of various etiologies. Strengthening trophics and activity at the cellular and tissue levels, drug makes "Placentex" indispensable for aesthetic medicine (including - mesotherapy). Thanks to the extraordinary popularity and the broadest spectrum of the drug, there was need to develop this line of products. Successfully passed the test preparation and in our country, supported by a certificate of the Ministry of Public Health. Exclusive distributor of the drug "Placentex" is the company "VIP-clinics". There appeared new - gel - revitalizant "Plinest. It is a ready-made form of a syringe volume of 1.3 ml. The drug is manufactured on the basis of polidezoksiribonukleotidnogo complex - PDRN. Raw material for the production of this drug is a natural raw materials - milk trout fish. The structure - a fraction of the DNA molecule. Compared with the drug "Placentex", "Plinest" has a higher molecular weight and molecule as long. It also stimulates the natural regeneration of tissues, activating the work of fibroblasts. Rates therapy Plinest "less long, the results are kept much longer.